Saif is the son of Bollywood actress, Sharmila Tagore, and Indian cricketer, Mansoor Ali Khan.
Both his grandfather, Iftikhar Ali Khan Pataudi, and father were professional cricketers. His mother, Sharmila Tagore, an actress within her own rights. He has two sisters, Bollywood actress Soha Ali Khan, and fashion designer Saba Ali Khan.