He started his film career by playing Glen Lantz in the 1984 horror film A Nightmare on Elm Street. He also appeared in the 1986 film Platoon with Charlie Sheen, Tom Berenger, and Willem Dafoe. In the 1990s, he starred as the title characters in the films Cry-Baby (1990), Edward Scissorhands (1990), Arizona Dream (1993), What's Eating Gilbert Grape (1993), Benny & Joon (1993), Ed Wood (1994), Don Juan DeMarco (1995), Dead Man (1995) and Donnie Brasco (1997). He also starred in Fear and Loathing in Las Vegas as Hunter S. Thompson (1998), The Ninth Gate as Dean Corso (1999), and Sleepy Hollow as Ichabod Crane (1999).
In the 2000s, he was in the films Chocolat , Blow, Once Upon a Time in Mexico, Finding Neverland, Secret Window, Charlie and the Chocolate Factory, Sweeney Todd, and Public Enemies. He plays Captain Jack Sparrow in the Pirates of the Caribbean series. For his roles in The Curse of the Black Pearl. Depp was nominated for an Academy Award for Best Actor.