These selected films -- which vary in quality, by the way -- have dominated the fantasy and science fiction genres in ways that few others have. Some (The Hobbit, The Lord of the Rings, Harry Potter, etc.) were preceded by books of the same name. Others (Star Trek, Star Wars, etc.) have spawned an "after the fact" publishing industry. I have not included franchises (however worthy) which seemed to target specifically the "YA" audience, but rather films with a broader appeal.
Movies announced, but yet to be released, are not included in this list.