Imagine the hilarity between Jim Carey and Steve Carell. With the Superbad boys being Biff's muscle.
*Accent issue: Marty McFly's mothers side would be British and his fathers side would be American. Both the brother and sister of Marty McFly would take after their father Steve Carell. So they would speak in an American accent.
*Explanation on the accent and possible location change is do to Marty going back in time and accidentally altering his mothers grandparents move to America. With the butterfly effect it changed more than one outcome so the whole cast is changed. They all are still the original characters but it's an altered reality.
*Car used instead of a DeLorean would be a Mercedes-Benz SLS AMG dressed similar to a DeLorean. They would have to reach a speed of 108 instead of the 88.
***Some of the finances of course would come from Mercedes. Because the car being in the movie would be a major promotion of their company and vehicle.